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By Ngu T. T. V.

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For example, for schizophrenia, estimates of the heritability of liability sometimes exceed 80%, even though the concordance for identical twins is less than 50%. It is important to emphasize that the heritability ofliability refers to a hypothetical construct of an underlying continuous liability toward a disorder, not to the disorder as diagnosed (Plomin, 1991). There is good reason to believe that mUltiple-gene influences on complex disorders result in continuous dimensions rather than dichotomous disorders.

1992). Sequence identification of 2,375 human brain genes. Nature, 355, 632-634. , et al. (1987). Genetic linkage between X chromosome markers and bipolar affective illness. Nature, 326, 289-292. , et al. (1993). Diminished support for linkage between manic depressive illness and x-chromosome markers in three Israeli pedigrees. Nature Genetics, 3,49-55. Bassett, A. , & Honer, W. G. (1994). Evidence for anticipation in schizophrenia. American Journal of Human Genetics, 54, 864-870. Bassett, A. , McGillivray, B.

They are generated without knowledge of the chromosomallocation(s) of the gene(s) controlling the trait; in fact, once generated, they can direct the search for such locations. Thus, in actuality, RDA represents neither functional nor positional cloning. , 1994). In extending this approach to human diseases, significantly inbred popUlations may be particularly informative. Statistical Genetics Statistical genetics represents the third pillar of contemporary human genetics, and here, too, rapid advances promise to pave the way to the identification of psychiatric susceptibility genes.

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