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Heppner G. Tumor heterogeneity. Cancer Res 1984; 44: 2259–2265. 7. Nicolson GL. Generation of phenotypic diversity and progression in metastatic tumors. Cancer Metastasis Rev 1984; 3:25–42. 8. Killion JJ, Kollmorgen GM. Isolation of immunogenic tumor cells by cell-affinity chromatography. Nature 1976; 259:674–676. 9. Kerbel RS. Implications of immunological heterogeneity in tumors. Nature 1979; 280:358–360. 10. Killion JJ. Immunotherapy with tumor subpopulations. II. Therapy of drug-resistant L1210 leukemia and E14 lymphoma.

2. Fidler IJ, Balch CM. The biology of cancer metastasis and implications for therapy. Curr Prob Surg 1987; 24: 131–233. 3. Killion JJ, Fidler IJ. The biology of tumor metastasis. Semin Oncol 1989; 16:106–115. 4. Bishop MJ. The molecular genetics of cancer. Science 1987; 235:305–311. 5. Poste G, Fidler IJ. The pathogenesis of cancer metastasis. Nature 1980; 283:139–146. 6. Heppner G. Tumor heterogeneity. Cancer Res 1984; 44: 2259–2265. 7. Nicolson GL. Generation of phenotypic diversity and progression in metastatic tumors.

88. Baker CH, Kedar D, McCarty MF, Tsan R, Weber KL, Bucana CD, Fidler IJ. Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas. Am J Pathol 2002; 161:929–938. 89. Bruns CJ, Shrader M, Harbison MT, Portera C, Solorzano CC, Jauch KW, Hicklin DJ, Radinsky R, Ellis LM. Effect of the vascular endothelial growth factor receptor-2 antibody DC101 plus gemcitabine on growth, metastasis and angiogenesis of human pancreatic cancer growing orthotopically in nude mice.

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