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1972). A comparison of rabbit and human skin response to certain irritants. Toxicol. Appl. Pharmacol. 21,369-382. , and Ferguson, T. F. M. (1976). The effect of surfactants upon rat peritoneal mast cells in vitro. Fd. Chem. Toxicol. 14, 425. Reinhardt, C. , and Spengler, J. (1987). Validation of three cell toxicity tests and the hen's egg test with guinea pig eye and human skin irritation data. In Alternative Methods in Toxicology (A. M. ), Vol. 5. Liebert, New York. , Akers, W. , McCreesh, A.

Russell, W. M. , and Burch, R. L. (1959). The Principles of Humane Experimental Technique. Methuen, London. CHAPTER 3 Tests for Dermal Irritation and Corrosion Evaluation of materials for their potential to cause dermal irritation and corrosion due to acute contact has been common for industrial chemicals, cosmetics, agricultural chemicals, and consumer products since at least the 1930s (generally, pharmaceuticals are only evaluated for dermal effects if they are to be administered topically--and then by repeat exposure tests, which will not be addressed here).

1989). Comparisons of the cytotoxicities of dermatotoxicants to human keratinocytes and fibroblasts in vitro. In In Vitro Toxicology: New Directions (A. M. ), pp. 153-167. Liebert, New York. 54 Acute Toxicology Testing Bartnik, F. , Pittermann, W. , and Kunstler, K. (1989). Skin organ culture for the study of skin irritancy. Third International Congress of Toxicology, Brighton, UK. , et al. (1989). Use of fabricated living tissue and organ equivalents as defined in higher order systems for the study of pharmacologic responses to test substances.

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