By Andreas D. Baxevanis, B. F. Francis Ouellette
"In this e-book, Andy Baxevanis and Francis Ouellette . . . have undertaken the tough activity of organizing the data during this box in a logical development and offering it in a digestible shape. they usually have performed a superb activity. This superb textual content will make an enormous influence on organic learn and, in flip, on growth in biomedicine. we're all of their debt."
—Eric Lander from the Foreword
Reviews from the 1st Edition
"...provides a large review of the fundamental instruments for series research ... For biologists drawing close this topic for the 1st time, it will likely be a really important guide to maintain at the shelf after the 1st interpreting, just about the computer."
—Nature Structural Biology
"...should be within the own library of any biologist who makes use of the web for the research of DNA and protein series data."
"...a amazing primer designed to navigate the amateur in the course of the intricacies of in scripto research ... The entire gene searcher also will locate this ebook an invaluable addition to their library ... a great connection with the rules of bioinformatics."
—Trends in Biochemical Sciences
This re-creation of the hugely winning Bioinformatics: a realistic advisor to the research of Genes and Proteins presents a legitimate origin of easy strategies, with functional discussions and comparisons of either computational instruments and databases correct to organic research.
Equipping biologists with the fashionable instruments essential to remedy functional difficulties in series facts research, the second one variation covers the extensive spectrum of subject matters in bioinformatics, starting from net recommendations to predictive algorithms used on series, constitution, and expression info. With chapters written by way of specialists within the box, this up to date reference completely covers very important thoughts and is suitable for either the amateur and the skilled practitioner. Written in transparent, easy language, the publication is obtainable to clients with no a sophisticated mathematical or laptop technological know-how history. This new version includes:* All new end-of-chapter net assets, bibliographies, and challenge units* Accompanying website containing the solutions to the issues, in addition to hyperlinks to proper net assets* New assurance of comparative genomics, large-scale genome research, series meeting, and expressed series tags* A thesaurus of generic phrases in bioinformatics and genomics
Bioinformatics: a pragmatic advisor to the research of Genes and Proteins, moment variation is key interpreting for researchers, teachers, and scholars of all degrees in molecular biology and bioinformatics, in addition to for investigators excited by genomics, positional cloning, medical study, and computational biology.
Read or Download Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins (2nd Edition) PDF
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Extra resources for Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins (2nd Edition)
For this reason, the speciﬁcation provides two alternative forms of author name representation: one a simple string and the other a structured form with ﬁelds for last name, ﬁrst name, and so on. When data are submitted directly to NCBI or in cases when there is a consistent format of author names from a particular source (such as MEDLINE), the structured form is used. When the form cannot be deciphered, the author name remains as a string. This limits its use for retrieval but at least allows data to be viewed when the record is retrieved by other means.
Number of Hits Returned for Four Deﬁned Search Queries on Some of the More Popular Search and Meta-Search Engines Search Engine Search Term Meta-Search Engine HotBot Excite Infoseek Lycos Google MetaCrawler SavvySearch 478 1,040 Genetic mapping 13,213 34,760 Human genome 735 279 Positional cloning 14,044 53,940 Prostate cancer 4,326 15,980 1,143 24,376 9,395 7,043 19,536 19,797 666 3,987 33,538 23,100 62 42 40 0 58 54 52 57 16 B I O I N F O R M AT I C S A N D T H E I N T E R N E T collect the results, ﬁlter out duplicates, and return a single, annotated list to the user.
For that reason, basic observations have been chosen as the central data elements, with interpretations and nomenclature (elements more subject to change) being placed outside the basic, core representation of the data. Taking all factors into account, NCBI uses four core data elements: bibliographic citations, DNA sequences, protein sequences, and three-dimensional structures. In addition, two projects (taxonomy and genome maps) are more interpretive but nonetheless are so important as organizing and linking resources that NCBI has built a considerable base in these areas as well.