Download Biomarkers of Brain Injury and Neurological Disorders by Kevin K. W. Wang, Zhiqun Zhang, Firas H. Kobeissy PDF

By Kevin K. W. Wang, Zhiqun Zhang, Firas H. Kobeissy

This ebook explores the new advances within the concepts and systems utilized in biomarker learn that experience revolutionized the best way we examine, diagnose, and deal with mind harm stipulations. The members describe varied biomarker stories concerning mind damage and different neurological issues and research the various types and applied sciences used to spot those organic markers. The booklet comprises findings from "Omics examine" which were applied to decipher and determine such biomarkers. It discusses protein, microRNA, and adjusted gene profiles and experiences neurological problems equivalent to a number of sclerosis, Charcot-Marie-Tooth illness, and prion and Alzheimer’s disease.

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The collected data cannot be manually treated and studied due to its abundance, thus data Proteomics and Systems Biology in TBI 23 mining using computational tools is a must in order to handle the huge amount of the collected datasets. , 2012). , 2012). In vitro experiments on brain biopsy to simulate TBI or performing clinical trials for developing treatments for TBI is not an option. , 2013) and try to find out accurate networks that can describe and simulate the pathophysiology of TBI. The challenge of treating and anticipating secondary damage in TBI can be handled by systems biology through constructing a system scale model to detect and treat TBI, to handle the observations and come up with hypothesis that can be tested and fed back to the system to optimize the results of the model and get insight into the underlying pathophysiology and possible diagnostic and therapeutic modules.

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2011. Genomic, transcriptomic, and epigenomic approaches to recovery after acquired brain injury. PM&R. 3: S52–S58. , Y. Sanchez-Ruiz, A. Bachi, L. Beretta, E. Grandi, M. Beltramo and M. Alessio. 2004. Proteome study of human cerebrospinal fluid following traumatic brain injury indicates fibrin (ogen) degradation products as trauma-associated markers. J Neurotraum. 21: 854–863. , L. V. C. M. D. R. D. Hemphill. 2011. Surveillance for traumatic brain injury-related deaths—United States, 1997–2007.

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