By Susanne Zeilinger, Juan-Francisco Martín, Carlos García-Estrada
Fungi produce many chemically diversified secondary metabolites whose organic roles principally stay elusive. in the expanding variety of sequenced fungal genomes a number of very important genes concerned with secondary metabolite formation were pointed out. almost all these genes are clustered and their coordinated transcription is managed in a fancy method via either slim pathway-specific regulators in addition to wide international transcription components aware of environmental cues. lately it used to be came upon a few of the newly pointed out gene clusters are silent lower than laboratory stipulations suggesting that the biosynthetic strength of fungi is way from being exploited. in addition to determining novel bioactive metabolites from nonetheless unexplored assets, the activation of those gene clusters by means of numerous ways may end up within the discovery of latest ingredients with antibiotic and pharmaceutical merits. This publication covers contemporary advances within the box of fungal secondary metabolisms starting from methodologies to organic points and should contain the newest wisdom on fungal molecular biology, genomics, and metabolomics. With the similar quantity through Professor Juan-Francisco Martin, the place the main suitable and well-studied fungal secondary metabolites are compiled, this ebook presents a finished assessment of the cutting-edge of analysis on fungal secondary metabolites.
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Additional resources for Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2
Mol Gen Genet 260:462–469 74. Gajiwala KS, Burley SK (2000) Winged helix proteins. Curr Opin Struct Biol 10:110–116 75. Hoff B, Schmitt EK, Kück U (2005) CPCR1, but not its interacting transcription factor AcFKH1, controls fungal arthrospore formation in Acremonium chrysogenum. Mol Microbiol 56:1220–1233 76. Bayram O, Braus GH (2012) Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins. FEMS Microbiol Rev 36(1):1–24 77. Feng GH, Leonard TJ (1998) Culture conditions control expression of the genes for aflatoxin and sterigmatocystin biosynthesis in Aspergillus parasiticus and A.
As dimers, bZIPs target palindromic DNA sequences. 2 [21, 40–69]) have been characterized as stress response transcription factors, responding to a variety of environmental stresses that appears to link them to SM production [60, 71, 72]. bZIPs associated with SM regulation and stress include RsmA regulating sterigmatocystin and asperthecin in A. nidulans and gliotoxin in A. fumigatus [64, 65], AtfB regulating aflatoxin in Aspergillus parasiticus , and Aoyap1 regulating ochratoxin in Aspergillus ochraceus .
Appl Environ Microbiol 60:2408–2414 18. Chang P-K, Ehrlich KC, Yu J, Bhatnagar D, Cleveland TE (1995) Increased expression of Aspergillus parasiticus aflR, encoding a sequence-specific DNA-binding protein, relieves nitrate inhibition of aflatoxin biosynthesis. Appl Environ Microb 61:2372–2377 19. Chiang Y-M, Szewczyk E, Davidson AD, Keller N, Oakley BR, Wang CCC (2009) A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans.