Download Chromosome 12 Aberrations in Human Solid Tumors: by G. Stenman, J. Bullerdiek, S. Bartnitzke, P. Sahlin, E. PDF

By G. Stenman, J. Bullerdiek, S. Bartnitzke, P. Sahlin, E. Röijer, J. Mark (auth.), Prof. Dr. J. Bullerdiek, Dr. S. Bartnitzke (eds.)

Researchers eager about the cytogenetics and molecular genetics of human tumors will welcome this finished assessment of the kind of aberrations that chromosome 12 provides in human stable tumors. The authors learn the results for a cytogenetic subtyping of the tumors concerned and methods for deciding upon the molecular alterations which underlie the karyotypic changes.
The aberrations of chromosome 12 which the publication bargains with are very common chromosomal changes in human tumors occuring in widespread benign mesenchymal tumors, corresponding to uterine leiomyomas and lipomas, and in tumors of epithelial beginning, comparable to pleomorphic adenomas of the salivary glands.

Show description

Read or Download Chromosome 12 Aberrations in Human Solid Tumors: Cytogenetics and Molecular Genetics PDF

Similar genetics books

Principles of Psychiatric Genetics

Issues of habit symbolize probably the most universal and disabling ailments affecting humankind; notwithstanding, regardless of their world wide distribution, genetic impacts on those health problems are usually neglected by means of households and psychological healthiness execs. Psychiatric genetics is a swiftly advancing box, elucidating the numerous roles of particular genes and their interactions in mind improvement and dysregulation.

Genetic Predisposition to Cancer

This ebook examines the rules underlying genetic predisposition to melanoma so that it will familiarise training oncologists, geneticists and different pros drawn to melanoma with this new and multiplied box. The insurance is entire, taking the reader from an advent to genetic predisposition, via a dialogue of the molecular biology and statistical ideas excited by the detection and cloning of predisposition genes to a attention of familial melanoma syndromes, encompassing infrequent and customary cancers.

The Missing Gene: Psychiatry, Heredity, And the Fruitless Search for Genes

What factors psychiatric problems to seem? Are they essentially the results of humans s environments, or in their genes? more and more, we're informed that study has proven the significance of genetic affects on psychiatric problems comparable to schizophrenia, bipolar affliction, autism, and attention-deficit/hyperactivity illness (ADHD).

Opportunities in engineering careers

Describes the diversity of careers on hand in the box of engineering, discusses classical and glossy engineering specialties in addition to engineering know-how, and explains tips on how to develop into an engineer.

Additional resources for Chromosome 12 Aberrations in Human Solid Tumors: Cytogenetics and Molecular Genetics

Example text

1986; Mandahl et al. 1987, 1988; Dal ein et al. 1988a, 1992; De lang et al. 1988; Peulve et al. • Fig. 2. Metaphase cell from an atypicallipoma with a large, supernumerary ring chromosome • Fig. 3. Metaphase cell from an atypical lipoma showing a giant marker chromosome 32 N. Mandahl 1990; Sreekantaiah et a1. 1991c; Ohjimi et a1. 1992). These include 15 typical lipomas, two Iipoblastomas, one myxolipoma, one hibernorna, and one renal angiomyolipoma. The aberrations and localization of breakpoints in these tumors seem, possibly with a few exceptions, to be random.

1992). The second point of interest is the mechanism by which the rings and the giant marker occurred, bearing in mind the absence at their centromeric area of any of the alpha-satellite ONA sequences tested, as reported in another giant marker in WOLPS (Stephenson et al. 1992), and the "harlequin" pattern of involvement of sequences from several distinctive chromosomes. Acknowledgements. This work was supported by CNRS and grants from INSERM, the Caisse Regionale d' Assurances Maladies, the Association pour la Recherche sur le Cancer, and the Federation des Centres de Lutte Contre le Cancer, France.

Cancer Genet Cytogenet 32:25-31 Vanni R, Lecca U (1988) Involvement of the long arm of chromosome &2 in chromosome rearrangements of uterine leiomyoma. Cancer Genet Cytogenet 32:33-34 Vanni R, Nieddu M, Paoli R, Lecca U (1989) Uterine leiomyoma cytogenetics. 1. Rearrangements of chromosome 12. Cancer Genet Cytogenet 37:49-54 Vanni R, Dal Cin P, Van Den Berghe H (1990) Is the chromosome band Ip36 another hot-spot for rearrangements in uterine leiomyoma? Genes Chrom Cancer 2:255-256 Vanni R, Lecca U, Faa G (1991) Uterine leiomyoma cytogenetics.

Download PDF sample

Rated 4.07 of 5 – based on 14 votes