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By G. Obe (Editor), A. T. Natarajan (Editor)

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Additional resources for Chromosome Aberrations (Reprint of Cytogenetic and Genome Research 2004)

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Hypothetical distributions of DNA randomly cleaved to a particular number-average molecular weight were fit to the logistic gel mobility function to determine how such a randomly cleaved distribution of a particular cleavage frequency would be displayed along the experimental gel. This revealed a rapidly repaired kinetic fraction that represented 17 % of the Alu-probed signal (R-band DNA), almost none of the L1 probed signal (G-band DNA), and reflects transcription coupled repair of active genes.

Southern blots were imaged using a Molecular Dynamics, Inc. Storm 850 PhosphoImager. Images were cropped, rotated, and saved as 16 bits/pixel TIFF files using ImageQuant Tools v. 0. Lanes in the images were outlined by a rectangle that included signal from the entire lane. 0 software package and saved as Excel files. To determine the parameters for fitting logistic curves to the mobility of Mr standards, logistic regression was done using the Regression Wizard option of SigmaPlot version 4, SPSS, Inc.

TLS: trans-lesion synthesis. NER: nucleotide excision repair. Discussion We have studied chromosomal effects of the impaired NHEJ and HR repair pathways in DT40 cells in response to ICL-inducing agent, MMC. , 2000, 2001) clearly show that the HR pathway presents a critical determinant of the level of spontaneous and MMC-induced CAs and SCEs. However, a striking difference in chromosomal effects among mutants indicates that the consequences are different depending on the components of the HR repair pathway that are impaired.

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