By Moore R. L.
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Extra info for Concerning Paths That Do Not Separate a Given Continuous Curve
Feinbaum, R. and Ambros, V. (2004). A short history of a short RNA. Cell, 116, S89–92, 81 p following S96. Lee, R. , Hammell, C. M. and Ambros, V. (2006). Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans. RNA, 4, 589–597. , Han, J. et al. (2003). The nuclear RNase III Drosha initiates microRNA processing. Nature, 425, 415–419. Lewis, B. , Shih, I. , Jones-Rhoades, M. , Bartel, D. P. and Burge, C. B. (2003). Prediction of mammalian microRNA targets. Cell, 115, 787–798.
Despite considerable attention to microRNAs over the past five years, a lot of questions remain unanswered. The mechanism of action of microRNAs is still controversial and only few in vivo functions of microRNAs have been demonstrated in any organism to date. In C. 2). Given that C. elegans offers powerful forward and reverse genetic approaches combined with a phenotypic analysis at the cellular level, one might hope that C. elegans will continue to make important contributions to our understanding of microRNA biology.
B. (2004). Patterns of flanking sequence conservation and a characteristic upstream motif for microRNA gene identification. RNA, 10, 1309–1322. Pasquinelli, A. , Reinhart, B. , Slack, F. et al. (2000). Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature, 408, 86–89. The microRNAs of C. elegans Pillai, R. , Bhattacharyya, S. , Artus, C. G. et al. (2005). Inhibition of translational initiation by let-7 microRNA in human cells. Science, 309, 1573–1576.