Download Coronavirus replication and reverse genetics by Luis Enjuanes PDF

By Luis Enjuanes

Human coronaviruses brought on the SARS epidemic that contaminated greater than 8000 humans, killing approximately ten percentage of them in 32 nations. This e-book offers crucial details on those viruses and the improvement of vaccines to regulate coronavirus infections.

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Of interest, a similar mechanism was recently proposed for proofreading by RNA polymerases, where the polymerase pauses, retracts, removes several nucleotides from the nascent 30 end, and then resynthesizes this region (Shaevitz et al. 2003). Several gene products of ORF1b of coronaviruses and SARS CoV were identified that might function in such a proofreading mechanism, some of which are predicted to have nuclease activity (Snijder et al. 2003). If retraction occurred when the coronavirus polymerase was transcribing the IGS, the exposed 30 end of the nascent minus strand would relocate and align precisely to complementary sequences at the 30 side of the leader RNA at the 50 end of the genome and complete transcription of the subgenomic minus-strand RNA.

Several gene products of ORF1b of coronaviruses and SARS CoV were identified that might function in such a proofreading mechanism, some of which are predicted to have nuclease activity (Snijder et al. 2003). If retraction occurred when the coronavirus polymerase was transcribing the IGS, the exposed 30 end of the nascent minus strand would relocate and align precisely to complementary sequences at the 30 side of the leader RNA at the 50 end of the genome and complete transcription of the subgenomic minus-strand RNA.

Packaged into virions) could serve directly as templates for minus strand synthesis and result in the replication of the subgenomic mRNA. In our model (Sawicki and Sawicki 1995), which we called by the awkward name of “discontinuous extension of minus-strand RNA”, the minus-strand templates for subgenomic mRNAs would be made directly from the genome and would utilize a discontinuous transcription process. G. L. Sawicki and then relocate to the 50 end of the genome to finish transcription. This would result in the minus strand acquiring a sequence complementary to the 50 leader sequence and activating it as a template for subgenomic mRNA synthesis.

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